Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50427903
Substrate
n/a
Meas. Tech.
ChEMBL_940979 (CHEMBL2330669)
IC50
100±n/a nM
Citation
Van Zandt, MC; Whitehouse, DL; Golebiowski, A; Ji, MK; Zhang, M; Beckett, RP; Jagdmann, GE; Ryder, TR; Sheeler, R; Andreoli, M; Conway, B; Mahboubi, K; D'Angelo, G; Mitschler, A; Cousido-Siah, A; Ruiz, FX; Howard, EI; Podjarny, AD; Schroeter, H Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem 56:2568-80 (2013) [PubMed] Article
More Info.:
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK