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Target
DNA polymerase iota
Ligand
BDBM50428818
Substrate
n/a
Meas. Tech.
ChEMBL_949378 (CHEMBL2339793)
IC50
>200000±n/a nM
Citation
 Kuriyama, I; Miyazaki, A; Tsuda, Y; Yoshida, H; Mizushina, Y Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymeraseß. Bioorg Med Chem 21:403-11 (2012) [PubMed]  Article 
Target
Name:
DNA polymerase iota
Synonyms:
DNA polymerase iota | Eta2 | POLI | POLI_HUMAN | RAD30 homolog B | RAD30B
Type:
PROTEIN
Mol. Mass.:
82997.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100972
Residue:
740
Sequence:
MEKLGVEPEEEGGGDDDEEDAEAWAMELADVGAAASSQGVHDQVLPTPNASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHMEDFPKDKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFKQLPVDIQEEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQVSSVSPCEPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFPNLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVDEKITFPSDIDPQVFYELPEAVQKELLAEWKRAGSDFHIGHK
  
Inhibitor
Name:
BDBM50428818
Synonyms:
CHEMBL3142662
Type:
Small organic molecule
Emp. Form.:
C30H37N3O5
Mol. Mass.:
519.6319
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12 |r|
Structure:
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