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Target
Cannabinoid receptor 1
Ligand
BDBM50429401
Substrate
n/a
Meas. Tech.
ChEMBL_949033 (CHEMBL2343203)
Ki
287±n/a nM
Citation
 Manca, I; Mastinu, A; Olimpieri, F; Falzoi, M; Sani, M; Ruiu, S; Loriga, G; Volonterio, A; Tambaro, S; Bottazzi, ME; Zanda, M; Pinna, GA; Lazzari, P Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake. Eur J Med Chem 62:256-69 (2013) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_MOUSE | Cannabinoid CB1 receptor | Cannabinoid receptor | Cnr1
Type:
Enzyme
Mol. Mass.:
52842.52
Organism:
Mus musculus (Mouse)
Description:
P47746
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50429401
Synonyms:
CHEMBL2337202
Type:
Small organic molecule
Emp. Form.:
C23H22Cl3F3N4
Mol. Mass.:
517.802
SMILES:
Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(NN1CCCCC1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: