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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50430150
Substrate
n/a
Meas. Tech.
ChEMBL_942934 (CHEMBL2342883)
IC50
27±n/a nM
Citation
 Udagawa, S; Sakami, S; Takemura, T; Sato, M; Arai, T; Nitta, A; Aoki, T; Kawai, K; Iwamura, T; Okazaki, S; Takahashi, T; Kaino, M Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett 23:1617-21 (2013) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50430150
Synonyms:
CHEMBL2338261
Type:
Small organic molecule
Emp. Form.:
C23H27N3O2
Mol. Mass.:
377.4794
SMILES:
O[C@]12CC3CC(C1)[C@@H](C(C3)C2)N1CCCc2c(cnn2-c2ccccc2)C1=O |r,wU:7.13,1.0,TLB:9:8:2.3.4:6,THB:9:3:6:10.8.7,7:8:2:4.5.6,7:5:2:10.9.8,11:7:2.3.4:6,(30.86,-31.1,;29.32,-31.12,;30.53,-32.38,;29.03,-31.98,;29.02,-30.39,;27.97,-29.16,;29.32,-29.63,;26.57,-29.76,;26.6,-31.29,;27.62,-32.55,;28,-31.62,;25.4,-28.77,;25.77,-27.27,;24.83,-26.04,;23.3,-26,;22.31,-27.18,;22.62,-28.7,;21.27,-29.45,;20.14,-28.42,;20.78,-27.01,;20.02,-25.68,;20.8,-24.35,;20.04,-23.01,;18.5,-23,;17.72,-24.33,;18.48,-25.67,;23.99,-29.4,;23.96,-30.94,)|
Structure:
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