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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50430146
Substrate
n/a
Meas. Tech.
ChEMBL_942935 (CHEMBL2342884)
IC50
25±n/a nM
Citation
 Udagawa, S; Sakami, S; Takemura, T; Sato, M; Arai, T; Nitta, A; Aoki, T; Kawai, K; Iwamura, T; Okazaki, S; Takahashi, T; Kaino, M Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett 23:1617-21 (2013) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50430146
Synonyms:
CHEMBL2338265
Type:
Small organic molecule
Emp. Form.:
C24H29N3O2
Mol. Mass.:
391.506
SMILES:
CC1CN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c2C1)-c1ccccc1 |r,wU:4.3,11.12,TLB:8:7:14:10.9.4,8:9:13.7.6:14,4:5:13:10.8.9,THB:4:9:13:6.5.14,3:4:13.7.6:14,(10.99,-18.22,;10.29,-19.59,;11.22,-20.82,;10.85,-22.32,;12.03,-23.31,;13.42,-22.71,;14.47,-23.94,;14.48,-25.52,;13.08,-26.1,;12.05,-24.83,;13.45,-25.17,;14.77,-24.67,;16.31,-24.65,;15.98,-25.93,;14.77,-23.18,;9.45,-22.95,;9.41,-24.49,;8.07,-22.25,;6.73,-23,;5.59,-21.97,;6.23,-20.56,;7.77,-20.73,;8.75,-19.55,;5.47,-19.23,;6.26,-17.9,;5.5,-16.56,;3.96,-16.55,;3.18,-17.88,;3.94,-19.22,)|
Structure:
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