Reaction Details Report a problem with these data
Target
Proliferating cell nuclear antigen
Ligand
BDBM50431448
Substrate
n/a
Meas. Tech.
ChEMBL_952429 (CHEMBL2352795)
IC50
8600±n/a nM
Citation
 Actis, M; Inoue, A; Evison, B; Perry, S; Punchihewa, C; Fujii, N Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis. Bioorg Med Chem 21:1972-7 (2013) [PubMed]  Article 
Target
Name:
Proliferating cell nuclear antigen
Synonyms:
Cyclin | PCNA | PCNA_HUMAN
Type:
PROTEIN
Mol. Mass.:
28752.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_952429
Residue:
261
Sequence:
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS
  
Inhibitor
Name:
BDBM50431448
Synonyms:
CHEMBL2348301
Type:
Small organic molecule
Emp. Form.:
C20H14I3NO5S
Mol. Mass.:
761.107
SMILES:
Oc1ccc(Oc2c(I)cc(CC(=O)NS(=O)(=O)c3ccccc3)cc2I)cc1I
Structure:
Search PDB for entries with ligand similarity: