Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50259004
Substrate
n/a
Meas. Tech.
ChEMBL_950474 (CHEMBL2351226)
Ki
0.580000±n/a nM
Citation
 Li, Y; Wang, X; Zhang, J; Deuther-Conrad, W; Xie, F; Zhang, X; Liu, J; Qiao, J; Cui, M; Steinbach, J; Brust, P; Liu, B; Jia, H Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives ass1 receptor ligands for positron emission tomography imaging. J Med Chem 56:3478-91 (2013) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50259004
Synonyms:
1'-[4-Fluorobenzyl]-3H-spiro[[2]benzofuran-1,4'piperidine] | CHEMBL466289
Type:
Small organic molecule
Emp. Form.:
C19H20FNO
Mol. Mass.:
297.3666
SMILES:
Fc1ccc(CN2CCC3(CC2)OCc2ccccc32)cc1
Structure:
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