Reaction Details Report a problem with these data
Target
P2Y purinoceptor 1
Ligand
BDBM50433789
Substrate
n/a
Meas. Tech.
ChEMBL_958358 (CHEMBL2382617)
Ki
11±n/a nM
Citation
 Wang, TC; Qiao, JX; Clark, CG; Jua, J; Price, LA; Wu, Q; Chang, M; Zheng, J; Huang, CS; Everlof, G; Schumacher, WA; Wong, PC; Seiffert, DA; Stewart, AB; Bostwick, JS; Crain, EJ; Watson, CA; Rehfuss, R; Wexler, RR; Lam, PY Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility. Bioorg Med Chem Lett 23:3239-43 (2013) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
Enzyme
Mol. Mass.:
42090.25
Organism:
Homo sapiens (Human)
Description:
P47900
Residue:
373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
  
Inhibitor
Name:
BDBM50433789
Synonyms:
CHEMBL2381904
Type:
Small organic molecule
Emp. Form.:
C35H39FN4O3
Mol. Mass.:
582.7076
SMILES:
CC(C)(C)c1ccccc1Oc1ncccc1NC(=O)Nc1ccc(OCC2CCN(Cc3ccccc3)CC2)cc1F
Structure:
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