Reaction Details Report a problem with these data
Target
P2Y purinoceptor 1
Ligand
BDBM50433795
Substrate
n/a
Meas. Tech.
ChEMBL_958358 (CHEMBL2382617)
Ki
322±n/a nM
Citation
 Wang, TC; Qiao, JX; Clark, CG; Jua, J; Price, LA; Wu, Q; Chang, M; Zheng, J; Huang, CS; Everlof, G; Schumacher, WA; Wong, PC; Seiffert, DA; Stewart, AB; Bostwick, JS; Crain, EJ; Watson, CA; Rehfuss, R; Wexler, RR; Lam, PY Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility. Bioorg Med Chem Lett 23:3239-43 (2013) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
Enzyme
Mol. Mass.:
42090.25
Organism:
Homo sapiens (Human)
Description:
P47900
Residue:
373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
  
Inhibitor
Name:
BDBM50433795
Synonyms:
CHEMBL2381897
Type:
Small organic molecule
Emp. Form.:
C25H29FN4O2
Mol. Mass.:
436.5218
SMILES:
CN(C)Cc1ccc(NC(=O)Nc2cccnc2Oc2ccccc2C(C)(C)C)c(F)c1
Structure:
Search PDB for entries with ligand similarity: