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Target
Heme oxygenase 2
Ligand
BDBM50044424
Substrate
n/a
Meas. Tech.
ChEMBL_976174 (CHEMBL2415823)
IC50
24500±n/a nM
Citation
 Salerno, L; Pittalà, V; Romeo, G; Modica, MN; Siracusa, MA; Di Giacomo, C; Acquaviva, R; Barbagallo, I; Tibullo, D; Sorrenti, V Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. Bioorg Med Chem 21:5145-53 (2013) [PubMed]  Article 
Target
Name:
Heme oxygenase 2
Synonyms:
HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:
Enzyme
Mol. Mass.:
35754.99
Organism:
Rattus norvegicus (rat)
Description:
HO-2 obtained from rat brain was used in enzyme assays.
Residue:
315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
  
Inhibitor
Name:
BDBM50044424
Synonyms:
4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlorophenethyl)-1,3-dioxolan-4-yl)methylthio)benzenamine | 4-{(2S,4S)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethylsulfanyl}-phenylamine | 4-{2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethylsulfanyl}-phenylamine | Azalanstat dihydrochloride | CHEMBL70611
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O2S
Mol. Mass.:
429.963
SMILES:
Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Structure:
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