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Found 540 with Last Name = 'pittalà' and Initial = 'v'
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262788(2-[[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]thi...)
Affinity DataKi:  0.0940nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50143697(8-{2-[4-(2,5-Dichloro-phenyl)-piperazin-1-yl]-ethy...)
Affinity DataKi:  0.129nMAssay Description:Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50006952(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.269nMAssay Description:Displacement of [125I]BE-2254 from human adrenergic alpha1A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50006952(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.269nMAssay Description:Binding affinity to adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262744(2-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]th...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262787(2-[[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]thi...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50263290(2-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]th...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50006952(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.363nMAssay Description:Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50006952(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.363nMAssay Description:Binding affinity to adrenergic Alpha-1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418765(CHEMBL1796046)
Affinity DataKi:  0.501nMAssay Description:Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262790(2-[[6-[4-(2-Methoxyphenyl)-1-piperazinyl]hexyl]thi...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262578(2-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]th...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262582(2-[[3-[4-(Pyridin-2-yl)-1-piperazinyl]propyl]thio]...)
Affinity DataKi:  0.780nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262746(5-Chloro-2-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]...)
Affinity DataKi:  0.880nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50263289(2-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]th...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262745(5-Chloro-2-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50026917(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Affinity DataKi:  1.05nMAssay Description:Binding affinity to adrenergic Alpha-1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262790(2-[[6-[4-(2-Methoxyphenyl)-1-piperazinyl]hexyl]thi...)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as inhibition of 5-hydroxytryptamine-induced increase in [35S]GTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262789(2-[[6-[4-(2-Methoxyphenyl)-1-piperazinyl]hexyl]thi...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262639(2-[[3-[4-(Pyridin-2-yl)-1-piperazinyl]propyl]thio]...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50263290(2-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]th...)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as inhibition of 5-hydroxytryptamine-induced increase in [35S]GTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418752(CHEMBL1796033)
Affinity DataKi:  1.82nMAssay Description:Displacement of [125I]BE-2254 from human adrenergic alpha1A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50006952(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  1.82nMAssay Description:Binding affinity to adrenergic Alpha-1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50006952(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  1.82nMAssay Description:Displacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418752(CHEMBL1796033)
Affinity DataKi:  2nMAssay Description:Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50164345(6-(4-Methoxy-phenyl)-3-{3-[4-(2-methoxy-phenyl)-pi...)
Affinity DataKi:  2.11nMAssay Description:Inhibition of [3H]-spiperone binding to Dopamine receptor D2 from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262742(2-[[3-[4-(Pyrimidin-2-yl)-1-piperazinyl]propyl]thi...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418752(CHEMBL1796033)
Affinity DataKi:  2.51nMAssay Description:Antagonist activity at human adrenergic alpha1A receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50164355(6-(4-Chloro-phenyl)-3-{2-[4-(2-methoxy-phenyl)-pip...)
Affinity DataKi:  3.64nMAssay Description:Inhibition of [3H]-spiperone binding to Dopamine receptor D2 from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418752(CHEMBL1796033)
Affinity DataKi:  3.98nMAssay Description:Antagonist activity against human cloned adrenergic Alpha-1B receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-U-69,593 from Opioid receptor kappa 1 in guinea pig cerebellar.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418769(CHEMBL1796050)
Affinity DataKi:  5.01nMAssay Description:Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50091002(2-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]-U-69,593 from Opioid receptor kappa 1 in guinea pig cerebellar.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50005127(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  5.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064195((2S,6R,11S)-6,11-Dimethyl-3-(2-phenylamino-ethyl)-...)
Affinity DataKi:  5.90nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262788(2-[[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]thi...)
Affinity DataKi:  6.60nMAssay Description:Antagonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as inhibition of 5-hydroxytryptamine-induced increase in [35S]GTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50090990(2-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]-U-69,593 from Opioid receptor kappa 1 in guinea pig cerebellar.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262832(3-amino-6-ethyl-2-(3-(4-(2-methoxyphenyl)piperazin...)
Affinity DataKi:  7.40nMAssay Description:Antagonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as inhibition of 5-hydroxytryptamine-induced increase in [35S]GTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064191((2S,6R,11S)-6,11-Dimethyl-3-(2-pyrrolidin-1-yl-eth...)
Affinity DataKi:  7.40nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418765(CHEMBL1796046)
Affinity DataKi:  7.94nMAssay Description:Antagonist activity against human cloned adrenergic Alpha-1B receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50262580(2-[[3-[4-(2-Nitrophenyl)-1-piperazinyl]propyl]thio...)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418769(CHEMBL1796050)
Affinity DataKi:  9.77nMAssay Description:Displacement of [125I]BE-2254 from human adrenergic alpha1A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418769(CHEMBL1796050)
Affinity DataKi:  10nMAssay Description:Antagonist activity at human adrenergic alpha1A receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50091014(2-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-U-69,593 from Opioid receptor kappa 1 in guinea pig cerebellar.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50418763(CHEMBL1796044)
Affinity DataKi:  10.2nMAssay Description:Displacement of [125I]BE-2254 from human adrenergic alpha1A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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