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Target
G-protein coupled receptor 39
Ligand
BDBM50443616
Substrate
n/a
Meas. Tech.
ChEMBL_1279426 (CHEMBL3096582)
EC50
56±n/a nM
Citation
 Boehm, M; Hepworth, D; Loria, PM; Norquay, LD; Filipski, KJ; Chin, JE; Cameron, KO; Brenner, M; Bonnette, P; Cabral, S; Conn, E; Ebner, DC; Gautreau, D; Hadcock, J; Lee, EC; Mathiowetz, AM; Morin, M; Rogers, L; Smith, A; VanVolkenburg, M; Carpino, PA Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example. ACS Med Chem Lett 4:1079-84 (2013) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 39
Synonyms:
GPR39 | GPR39_HUMAN
Type:
PROTEIN
Mol. Mass.:
51351.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107977
Residue:
453
Sequence:
MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
  
Inhibitor
Name:
BDBM50443616
Synonyms:
CHEMBL3092413
Type:
Small organic molecule
Emp. Form.:
C18H17ClN6
Mol. Mass.:
352.821
SMILES:
Clc1ccc2nc(CN3CCN(CC3)c3ccc(cn3)C#N)cn2c1
Structure:
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