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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50448703
Substrate
n/a
Meas. Tech.
ChEMBL_1297897 (CHEMBL3132110)
IC50
4.4±n/a nM
Citation
 Goldberg, FW; Dossetter, AG; Scott, JS; Robb, GR; Boyd, S; Groombridge, SD; Kemmitt, PD; Sjögren, T; Gutierrez, PM; deSchoolmeester, J; Swales, JG; Turnbull, AV; Wild, MJ Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. J Med Chem 57:970-86 (2014) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50448703
Synonyms:
CHEMBL3127859
Type:
Small organic molecule
Emp. Form.:
C18H24N2O3S
Mol. Mass.:
348.46
SMILES:
COc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:20.23,wD:13.14,TLB:12:13:17:19.20.22,23:20:13.14.15:17,THB:23:14:17:19.20.22,22:20:13:15.16.17,22:16:13:19.23.20,21:20:13:15.16.17,21:20:13.14.15:17,(1.49,-54,;2.65,-52.98,;4.11,-53.48,;4.56,-54.96,;6.1,-54.98,;6.99,-56.23,;7.13,-57.77,;8.39,-56.88,;6.6,-53.52,;5.37,-52.6,;7.93,-52.75,;7.92,-51.21,;9.26,-53.51,;10.6,-52.74,;12.1,-52.35,;12.12,-50.76,;13.18,-49.54,;11.83,-50,;11.81,-51.49,;13.13,-52,;14.53,-51.68,;16.07,-51.64,;14.57,-50.15,;13.5,-52.94,)|
Structure:
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