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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50448698
Substrate
n/a
Meas. Tech.
ChEMBL_1297892 (CHEMBL3132105)
IC50
14±n/a nM
Citation
 Goldberg, FW; Dossetter, AG; Scott, JS; Robb, GR; Boyd, S; Groombridge, SD; Kemmitt, PD; Sjögren, T; Gutierrez, PM; deSchoolmeester, J; Swales, JG; Turnbull, AV; Wild, MJ Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. J Med Chem 57:970-86 (2014) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50448698
Synonyms:
CHEMBL3127864
Type:
Small organic molecule
Emp. Form.:
C21H30N2O4S
Mol. Mass.:
406.539
SMILES:
COC[C@@H](C)Oc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:24.27,wD:17.18,3.3,TLB:16:17:21:23.24.26,27:24:17.18.19:21,THB:27:18:21:23.24.26,26:24:17:19.20.21,26:20:17:23.27.24,25:24:17:19.20.21,25:24:17.18.19:21,(42.84,-7.77,;44.29,-8.27,;45.45,-7.25,;46.91,-7.75,;47.21,-9.27,;48.07,-6.74,;49.53,-7.24,;49.98,-8.71,;51.52,-8.74,;52.41,-9.99,;52.55,-11.53,;53.81,-10.64,;52.02,-7.28,;50.79,-6.36,;53.35,-6.51,;53.34,-4.97,;54.69,-7.27,;56.02,-6.5,;57.52,-6.11,;57.54,-4.52,;58.6,-3.3,;57.25,-3.75,;57.23,-5.25,;58.55,-5.76,;59.96,-5.44,;61.5,-5.4,;60,-3.91,;58.92,-6.7,)|
Structure:
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