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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50448700
Substrate
n/a
Meas. Tech.
ChEMBL_1297892 (CHEMBL3132105)
IC50
13±n/a nM
Citation
 Goldberg, FW; Dossetter, AG; Scott, JS; Robb, GR; Boyd, S; Groombridge, SD; Kemmitt, PD; Sjögren, T; Gutierrez, PM; deSchoolmeester, J; Swales, JG; Turnbull, AV; Wild, MJ Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. J Med Chem 57:970-86 (2014) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50448700
Synonyms:
CHEMBL3127862
Type:
Small organic molecule
Emp. Form.:
C19H26N2O4S
Mol. Mass.:
378.486
SMILES:
OCCOc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:22.25,wD:15.16,TLB:14:15:19:21.22.24,25:22:15.16.17:19,THB:25:16:19:21.22.24,24:22:15:17.18.19,24:18:15:21.25.22,23:22:15:17.18.19,23:22:15.16.17:19,(2.26,-7.56,;3.42,-6.55,;4.87,-7.05,;6.03,-6.04,;7.49,-6.54,;7.94,-8.01,;9.48,-8.03,;10.37,-9.28,;10.51,-10.82,;11.77,-9.93,;9.98,-6.57,;8.75,-5.65,;11.31,-5.8,;11.31,-4.26,;12.65,-6.56,;13.98,-5.79,;15.48,-5.4,;15.5,-3.81,;16.57,-2.6,;15.21,-3.05,;15.19,-4.54,;16.51,-5.05,;17.92,-4.73,;19.46,-4.69,;17.96,-3.2,;16.88,-5.99,)|
Structure:
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