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Target
Histamine H3 receptor
Ligand
BDBM50001753
Substrate
n/a
Meas. Tech.
ChEMBL_1338135 (CHEMBL3242002)
Ki
43±n/a nM
Citation
 Sadek, B; Schwed, JS; Subramanian, D; Weizel, L; Walter, M; Adem, A; Stark, H Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties. Eur J Med Chem 77:269-79 (2014) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50001753
Synonyms:
CHEMBL3238446
Type:
Small organic molecule
Emp. Form.:
C18H29N3O2
Mol. Mass.:
319.4418
SMILES:
C[C@H](NCc1ccc(OCCCN2CCCCC2)cc1)C(N)=O |r|
Structure:
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