Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 4
Ligand
BDBM50003020
Substrate
n/a
Meas. Tech.
ChEMBL_1335112 (CHEMBL3239619)
IC50
44±n/a nM
Citation
Biftu, T; Sinha-Roy, R; Chen, P; Qian, X; Feng, D; Kuethe, JT; Scapin, G; Gao, YD; Yan, Y; Krueger, D; Bak, A; Eiermann, G; He, J; Cox, J; Hicks, J; Lyons, K; He, H; Salituro, G; Tong, S; Patel, S; Doss, G; Petrov, A; Wu, J; Xu, SS; Sewall, C; Zhang, X; Zhang, B; Thornberry, NA; Weber, AE Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem 57:3205-12 (2014) [PubMed] Article
More Info.:
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
Cd26 | DPP4_MOUSE | Dipeptidyl peptidase IV | Dpp4
Type:
PROTEIN
Mol. Mass.:
87433.73
Organism:
Mus musculus
Description:
ChEMBL_1335112
Residue:
760
Sequence:
MKTPWKVLLGLLGVAALVTIITVPIVLLSKDEAAADSRRTYSLADYLKSTFRVKSYSLWWVSDFEYLYKQENNILLLNAEHGNSSIFLENSTFESFGYHSVSPDRLFVLLEYNYVKQWRHSYTASYNIYDVNKRQLITEEKIPNNTQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHRITSTGEENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNIDSLSSSSSAAPIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDYDKINLTWNCPSEQQHVEMSTTGWVGRFRPAEPHFTSDGSSFYKIISDKDGYKHICHFPKDKKDCTFITKGAWEVISIEALTSDYLYYISNQYKEMPGGRNLYKIQLTDHTNVKCLSCDLNPERCQYYAVSFSKEAKYYQLGCWGPGLPLYTLHRSTDHKELRVLEDNSALDRMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADASFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPIPEDNLDHYRNSTVMSRAEHFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLH
Inhibitor
Name:
BDBM50003020
Synonyms:
MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin | US10479798, Compound MK3102 | US10822319, Compound Omarigliptin
Type:
Small organic molecule
Emp. Form.:
C17H20F2N4O3S
Mol. Mass.:
398.428
SMILES:
CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F |r|