Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50007228
Substrate
n/a
Meas. Tech.
ChEMBL_1338729 (CHEMBL3242200)
IC50
100±n/a nM
Citation
 DeMong, D; Dai, X; Hwa, J; Miller, M; Lin, SI; Kang, L; Stamford, A; Greenlee, W; Yu, W; Wong, M; Lavey, B; Kozlowski, J; Zhou, G; Yang, DY; Patel, B; Soriano, A; Zhai, Y; Sondey, C; Zhang, H; Lachowicz, J; Grotz, D; Cox, K; Morrison, R; Andreani, T; Cao, Y; Liang, M; Meng, T; McNamara, P; Wong, J; Bradley, P; Feng, KI; Belani, J; Chen, P; Dai, P; Gauuan, J; Lin, P; Zhao, H The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist. J Med Chem 57:2601-10 (2014) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GL-R | GLR_MOUSE | Gcgr
Type:
PROTEIN
Mol. Mass.:
54941.21
Organism:
Mus musculus
Description:
ChEMBL_1338729
Residue:
485
Sequence:
MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT
  
Inhibitor
Name:
BDBM50007228
Synonyms:
CHEMBL3238219
Type:
Small organic molecule
Emp. Form.:
C34H44FN7O2
Mol. Mass.:
601.7573
SMILES:
CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cccc(F)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(7.91,-30.88,;7.89,-29.34,;6.55,-28.59,;6.56,-30.1,;9.22,-28.56,;9.2,-27.02,;10.52,-26.23,;10.47,-24.7,;11.68,-23.74,;13.16,-24.16,;11.15,-22.3,;9.6,-22.36,;9.19,-23.83,;8,-22.85,;6.56,-23.38,;6.29,-24.9,;7.48,-25.88,;8.93,-25.35,;4.85,-25.43,;3.67,-24.45,;3.41,-25.96,;4.59,-26.95,;11.92,-20.97,;13.47,-20.98,;14.24,-19.65,;13.48,-18.31,;11.94,-18.3,;11.17,-16.96,;11.16,-19.63,;11.85,-27.02,;11.83,-28.56,;13.15,-29.35,;14.5,-28.59,;14.52,-27.06,;13.19,-26.27,;15.82,-29.39,;15.8,-30.92,;17.16,-28.63,;18.49,-29.42,;19.83,-28.66,;21.22,-29.3,;22.27,-28.17,;21.51,-26.82,;20,-27.13,)|
Structure:
Search PDB for entries with ligand similarity: