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Target
Gamma-butyrobetaine dioxygenase
Ligand
BDBM50008026
Substrate
n/a
Meas. Tech.
ChEMBL_1337520 (CHEMBL3242135)
IC50
24000±n/a nM
Citation
 Tars, K; Leitans, J; Kazaks, A; Zelencova, D; Liepinsh, E; Kuka, J; Makrecka, M; Lola, D; Andrianovs, V; Gustina, D; Grinberga, S; Liepinsh, E; Kalvinsh, I; Dambrova, M; Loza, E; Pugovics, O Targeting carnitine biosynthesis: discovery of new inhibitors against¿-butyrobetaine hydroxylase. J Med Chem 57:2213-36 (2014) [PubMed]  Article 
Target
Name:
Gamma-butyrobetaine dioxygenase
Synonyms:
BBH | BBOX | BBOX1 | BODG_HUMAN | Gamma-BBH | Gamma-butyrobetaine hydroxylase | Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Type:
PROTEIN
Mol. Mass.:
44715.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1434107
Residue:
387
Sequence:
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVENGN
  
Inhibitor
Name:
BDBM50008026
Synonyms:
CHEMBL3234383
Type:
Small organic molecule
Emp. Form.:
C8H15BrN2O2
Mol. Mass.:
251.121
SMILES:
[Br-].C[N+](C)(CC#C)NCCC(O)=O
Structure:
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