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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50013912
Substrate
n/a
Meas. Tech.
ChEMBL_1350259 (CHEMBL3267242)
EC50
49±n/a nM
Citation
 Alper, P; Azimioara, M; Cow, C; Mutnick, D; Nikulin, V; Michellys, PY; Wang, Z; Reding, E; Paliotti, M; Li, J; Bao, D; Zoll, J; Kim, Y; Zimmerman, M; Groessel, T; Tuntland, T; Joseph, SB; McNamara, P; Seidel, HM; Epple, R Discovery of structurally novel, potent and orally efficacious GPR119 agonists. Bioorg Med Chem Lett 24:2383-7 (2014) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_MOUSE | Gpr119
Type:
PROTEIN
Mol. Mass.:
37009.07
Organism:
Mus musculus
Description:
ChEMBL_1506420
Residue:
335
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
  
Inhibitor
Name:
BDBM50013912
Synonyms:
CHEMBL3260536
Type:
Small organic molecule
Emp. Form.:
C27H27F3N4O2
Mol. Mass.:
496.5241
SMILES:
COCCN(C)C(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Structure:
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