Found 888 with Last Name = 'cow' and Initial = 'c' 
Affinity DataKi: 6nMAssay Description:Binding affinity to human mu opioid receptor by radio-ligand binding assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 398nMAssay Description:Displacement of [125I]cyanopindolol from human cloned beta-1 adrenergic receptor expressed in Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 1.59E+3nMAssay Description:Displacement of [125I]cyanopindolol from human cloned beta-2 adrenergic receptor expressed in Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of SPPL2a in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Mus musculus)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of mouse SPPL2a cotransfected with EGFP-NLP-fused TNFalpha (1 to 77 residues)-NTF incubated for 24 hrs by Hoechst staining based Cellomics...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Mus musculus)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of SPPL2a in Balb/c mouse A20 cells assessed as reduction in CD74/p8 NTF accumulation incubated for overnight by Western blot analysisMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2B(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of SPPL2b in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 620nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Affinity DataIC50: 794nMAssay Description:Receptor binding assay(Beta-2 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 840nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 910nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Trevena
Curated by ChEMBL
Trevena
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Burroughs Wellcome
Curated by ChEMBL
Burroughs Wellcome
Curated by ChEMBL
Affinity DataIC50: 4.70E+3nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Affinity DataIC50: 5.01E+3nMAssay Description:Receptor binding assay(Beta-2 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
Affinity DataIC50: 5.01E+3nMAssay Description:Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Trevena
Curated by ChEMBL
Trevena
Curated by ChEMBL
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
