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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50014031
Substrate
n/a
Meas. Tech.
ChEMBL_1350257 (CHEMBL3267240)
EC50
243±n/a nM
Citation
 Alper, P; Azimioara, M; Cow, C; Mutnick, D; Nikulin, V; Michellys, PY; Wang, Z; Reding, E; Paliotti, M; Li, J; Bao, D; Zoll, J; Kim, Y; Zimmerman, M; Groessel, T; Tuntland, T; Joseph, SB; McNamara, P; Seidel, HM; Epple, R Discovery of structurally novel, potent and orally efficacious GPR119 agonists. Bioorg Med Chem Lett 24:2383-7 (2014) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50014031
Synonyms:
CHEMBL3260539
Type:
Small organic molecule
Emp. Form.:
C23H20F3N3O2S
Mol. Mass.:
459.484
SMILES:
CC(Cc1ccccc1)(c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F)S(C)(=O)=O
Structure:
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