Reaction Details Report a problem with these data
Target
P2Y purinoceptor 1
Ligand
BDBM50015296
Substrate
n/a
Meas. Tech.
ChEMBL_1349775 (CHEMBL3267607)
IC50
0.200000±n/a nM
Citation
 Hu, CH; Qiao, JX; Han, Y; Wang, TC; Hua, J; Price, LA; Wu, Q; Shen, H; Huang, CS; Rehfuss, R; Wexler, RR; Lam, PY 2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists. Bioorg Med Chem Lett 24:2481-5 (2014) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
Enzyme
Mol. Mass.:
42090.25
Organism:
Homo sapiens (Human)
Description:
P47900
Residue:
373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
  
Inhibitor
Name:
BDBM50015296
Synonyms:
CHEMBL3263076 | US9120798, 13
Type:
Small organic molecule
Emp. Form.:
C30H36ClN7OS
Mol. Mass.:
578.171
SMILES:
Cc1cc(-c2nnc(Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c3c(O)ccc4Cl)s2)n(C)n1
Structure:
Search PDB for entries with ligand similarity: