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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM50017306
Substrate
n/a
Meas. Tech.
ChEMBL_1362418 (CHEMBL3292526)
IC50
0.031623±n/a nM
Citation
 De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem 57:4661-76 (2014) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM50017306
Synonyms:
CHEMBL3287993
Type:
Small organic molecule
Emp. Form.:
C34H36FN5O4
Mol. Mass.:
597.6791
SMILES:
CN(C)Cc1cc(O)ccc1-c1cccc(Oc2ncc(F)cc2C(=O)N[C@@H]2CC[C@@H](CC2)NC(=O)c2cccc(C)n2)c1 |r,wU:30.35,27.28,(21.27,-30.02,;19.93,-29.26,;19.92,-27.72,;18.6,-30.03,;18.61,-31.58,;19.95,-32.34,;19.97,-33.89,;21.31,-34.65,;18.63,-34.66,;17.3,-33.9,;17.29,-32.36,;15.96,-31.59,;14.62,-32.38,;13.28,-31.6,;13.28,-30.06,;14.61,-29.3,;14.61,-27.76,;13.28,-26.98,;11.94,-27.76,;10.6,-26.98,;10.6,-25.44,;9.26,-24.67,;11.94,-24.67,;13.27,-25.43,;14.6,-24.66,;14.6,-23.12,;15.94,-25.42,;17.27,-24.65,;18.61,-25.42,;19.94,-24.65,;19.94,-23.11,;18.61,-22.34,;17.27,-23.11,;21.29,-22.34,;22.62,-23.11,;22.62,-24.65,;23.95,-22.34,;23.95,-20.81,;25.27,-20.05,;26.61,-20.81,;26.6,-22.35,;27.93,-23.12,;25.27,-23.12,;15.95,-30.06,)|
Structure:
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