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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM50017326
Substrate
n/a
Meas. Tech.
ChEMBL_1362418 (CHEMBL3292526)
IC50
0.100000±n/a nM
Citation
 De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem 57:4661-76 (2014) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM50017326
Synonyms:
CHEMBL3288015
Type:
Small organic molecule
Emp. Form.:
C35H38FN5O4S
Mol. Mass.:
643.771
SMILES:
Cc1nc(cs1)C(=O)N[C@H]1CC[C@H](CC1)NC(=O)c1cc(F)cnc1Oc1cccc(c1)-c1ccc(CN2CCCOCC2)cc1 |r,wU:9.9,12.16,(49.63,.92,;48.09,.87,;47.23,-.41,;45.75,.04,;45.7,1.57,;47.15,2.09,;44.53,-.91,;44.53,-2.46,;43.2,-.14,;41.85,-.91,;41.85,-2.46,;40.52,-3.22,;39.18,-2.45,;39.18,-.92,;40.52,-.14,;37.85,-3.22,;36.51,-2.46,;36.51,-.92,;35.18,-3.23,;33.84,-2.47,;32.51,-3.24,;31.17,-2.47,;32.5,-4.79,;33.85,-5.56,;35.19,-4.79,;36.52,-5.56,;36.52,-7.1,;35.19,-7.87,;35.19,-9.41,;36.53,-10.18,;37.86,-9.4,;37.86,-7.86,;39.2,-10.16,;39.2,-11.7,;40.54,-12.46,;41.87,-11.69,;43.21,-12.45,;43.22,-13.99,;44.59,-14.64,;44.95,-16.14,;44.01,-17.35,;42.47,-17.35,;41.5,-16.16,;41.83,-14.66,;41.86,-10.14,;40.52,-9.38,)|
Structure:
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