Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50362690
Substrate
n/a
Meas. Tech.
ChEMBL_1362994 (CHEMBL3292562)
EC50
104±n/a nM
Citation
 Liu, JJ; Wang, Y; Ma, Z; Schmitt, M; Zhu, L; Brown, SP; Dransfield, PJ; Sun, Y; Sharma, R; Guo, Q; Zhuang, R; Zhang, J; Luo, J; Tonn, GR; Wong, S; Swaminath, G; Medina, JC; Lin, DC; Houze, JB Optimization of GPR40 Agonists for Type 2 Diabetes. ACS Med Chem Lett 5:517-21 (2014) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50362690
Synonyms:
AMG-837 | CHEMBL1829173
Type:
Small organic molecule
Emp. Form.:
C26H21F3O3
Mol. Mass.:
438.4383
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1 |r|
Structure:
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