BDBM50362690 AMG-837::CHEMBL1829173
SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1
InChI Key InChIKey=ZOPNBMMVVZRSGH-NRFANRHFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 50362690
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillat...More data for this Ligand-Target Pair
Affinity DataKi: 42nMAssay Description:Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)...More data for this Ligand-Target Pair
Affinity DataEC50: 8.80E+3nMAssay Description:Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human seru...More data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human ser...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 155nMAssay Description:Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins...More data for this Ligand-Target Pair
Affinity DataEC50: 170nMAssay Description:Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization as...More data for this Ligand-Target Pair
Affinity DataEC50: 23nMAssay Description:Agonist activity at rat GPR40More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at mouse GPR40More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at GPR40 (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
Affinity DataEC50: 23nMAssay Description:Agonist activity at FFA1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 2.20nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at FFA1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.42E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measu...More data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as...More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arresti...More data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation i...More data for this Ligand-Target Pair
Affinity DataKd: 1.90nMAssay Description:Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human...More data for this Ligand-Target Pair
Affinity DataEC50: 104nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells by aequorin assayMore data for this Ligand-Target Pair
Affinity DataEC50: 41nMAssay Description:Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayMore data for this Ligand-Target Pair