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Target
Monoglyceride lipase
Ligand
BDBM50021980
Substrate
n/a
Meas. Tech.
ChEMBL_1367199
IC50
>500000±n/a nM
Citation
 Tuccinardi, T; Granchi, C; Rizzolio, F; Caligiuri, I; Battistello, V; Toffoli, G; Minutolo, F; Macchia, M; Martinelli, A Identification and characterization of a new reversible MAGL inhibitor. Bioorg Med Chem 22:3285-91 (2014) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50021980
Synonyms:
CHEMBL1458886
Type:
Small organic molecule
Emp. Form.:
C20H21FN6O2
Mol. Mass.:
396.4181
SMILES:
COc1ccc(cc1)-c1nnn(CC(=O)N2CCN(CC2)c2ccc(F)cc2)n1
Structure:
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