Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50021984
Substrate
n/a
Meas. Tech.
ChEMBL_1367199
IC50
>500000±n/a nM
Citation
 Tuccinardi, T; Granchi, C; Rizzolio, F; Caligiuri, I; Battistello, V; Toffoli, G; Minutolo, F; Macchia, M; Martinelli, A Identification and characterization of a new reversible MAGL inhibitor. Bioorg Med Chem 22:3285-91 (2014) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50021984
Synonyms:
CHEMBL3297867
Type:
Small organic molecule
Emp. Form.:
C25H19N3O4
Mol. Mass.:
425.4361
SMILES:
COc1ccc(CNC(=O)c2ccc3nc(-c4ccoc4)c(nc3c2)-c2ccoc2)cc1
Structure:
Search PDB for entries with ligand similarity: