Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50027938
Substrate
n/a
Meas. Tech.
ChEMBL_1436858 (CHEMBL3387231)
EC50
0.500000±n/a nM
Citation
 Horan, JC; Sanyal, S; Choi, Y; Hill-Drzewi, M; Patnaude, L; Anderson, S; Fogal, S; Mao, C; Cook, BN; Gueneva-Boucheva, K; Fisher, MB; Hickey, E; Pack, E; Bannen, LC; Chan, DS; Mac, MB; Ng, SM; Wang, Y; Xu, W; Modis, LK; Lemieux, RM Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists. Bioorg Med Chem Lett 24:4807-11 (2014) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50027938
Synonyms:
CHEMBL3344419
Type:
Small organic molecule
Emp. Form.:
C21H27ClFN5O3S
Mol. Mass.:
483.987
SMILES:
N[C@@H](CO)COc1cc(Cl)c(cc1F)-c1nnc(s1)N1CCN(CC1)C(=O)C1CCCC1 |r|
Structure:
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