Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM50027934
Substrate
n/a
Meas. Tech.
ChEMBL_1436859 (CHEMBL3387232)
EC50
>10000±n/a nM
Citation
 Horan, JC; Sanyal, S; Choi, Y; Hill-Drzewi, M; Patnaude, L; Anderson, S; Fogal, S; Mao, C; Cook, BN; Gueneva-Boucheva, K; Fisher, MB; Hickey, E; Pack, E; Bannen, LC; Chan, DS; Mac, MB; Ng, SM; Wang, Y; Xu, W; Modis, LK; Lemieux, RM Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists. Bioorg Med Chem Lett 24:4807-11 (2014) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM50027934
Synonyms:
CHEMBL3344415
Type:
Small organic molecule
Emp. Form.:
C22H22Cl2FN5O4
Mol. Mass.:
510.346
SMILES:
N[C@@H](CO)COc1cc(Cl)c(cc1F)-c1nc(no1)N1CCN(CC1)C(=O)c1cccc(Cl)c1 |r|
Structure:
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