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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50036644
Substrate
n/a
Meas. Tech.
ChEMBL_1434404 (CHEMBL3387656)
EC50
27±n/a nM
Citation
 Azimioara, M; Alper, P; Cow, C; Mutnick, D; Nikulin, V; Lelais, G; Mecom, J; McNeill, M; Michellys, PY; Wang, Z; Reding, E; Paliotti, M; Li, J; Bao, D; Zoll, J; Kim, Y; Zimmerman, M; Groessl, T; Tuntland, T; Joseph, SB; McNamara, P; Seidel, HM; Epple, R Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists. Bioorg Med Chem Lett 24:5478-83 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_MOUSE | Gpr119
Type:
PROTEIN
Mol. Mass.:
37009.07
Organism:
Mus musculus
Description:
ChEMBL_1506420
Residue:
335
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
  
Inhibitor
Name:
BDBM50036644
Synonyms:
CHEMBL3354781
Type:
Small organic molecule
Emp. Form.:
C27H24F3N3O2
Mol. Mass.:
479.4936
SMILES:
CCOC(=O)[C@@]1(Cc2ccccc2)CCCc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F |r|
Structure:
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