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Target
Mu-type opioid receptor
Ligand
BDBM50037081
Substrate
n/a
Meas. Tech.
ChEMBL_1435869 (CHEMBL3390730)
IC50
2.1±n/a nM
Citation
 Piekielna, J; Gentilucci, L; De Marco, R; Perlikowska, R; Adamska, A; Olczak, J; Mazur, M; Artali, R; Modranka, J; Janecki, T; Tömböly, C; Janecka, A Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine. Bioorg Med Chem 22:6545-51 (2015) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50037081
Synonyms:
CHEMBL3355779
Type:
Small organic molecule
Emp. Form.:
C40H49N7O7
Mol. Mass.:
739.8598
SMILES:
[H][C@]12CC[C@@]([H])(CC1)NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C2)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O |r,wU:43.47,38.43,27.29,16.17,1.0,wD:12.57,4.4,(8.11,-15.49,;9.74,-14.55,;9.73,-16.09,;11.06,-16.86,;12.4,-16.1,;11.46,-17.73,;12.4,-14.56,;11.07,-13.78,;12.42,-19.28,;13.6,-18.35,;14.92,-19.15,;13.63,-16.81,;14.98,-16.07,;15.02,-14.53,;16.37,-13.79,;17.68,-14.58,;16.41,-12.24,;17.75,-11.49,;19.08,-12.28,;19.05,-13.82,;20.37,-14.61,;21.72,-13.86,;21.74,-12.31,;20.41,-11.53,;15.08,-11.47,;13.74,-12.24,;13.74,-13.78,;12.41,-11.47,;12.41,-9.93,;13.74,-9.16,;15.08,-9.94,;16.42,-9.16,;16.42,-7.62,;15.08,-6.85,;13.74,-7.62,;11.07,-12.24,;9.74,-11.47,;9.74,-9.93,;8.41,-12.24,;8.41,-13.78,;7.07,-11.47,;5.74,-12.24,;5.74,-13.78,;4.41,-11.47,;3.07,-12.24,;4.41,-9.93,;5.74,-9.16,;7.08,-9.94,;8.41,-9.16,;8.41,-7.62,;9.75,-6.85,;7.08,-6.85,;5.74,-7.62,;16.3,-16.87,;16.27,-18.41,;17.65,-16.12,)|
Structure:
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