Reaction Details Report a problem with these data
Target
Cell cycle checkpoint protein RAD1
Ligand
BDBM48804
Substrate
n/a
Meas. Tech.
ChEMBL_1446559 (CHEMBL3377958)
EC50
27000±n/a nM
Citation
 Huang, F; Mazin, AV Targeting the homologous recombination pathway by small molecule modulators. Bioorg Med Chem Lett 24:3006-13 (2014) [PubMed]  Article 
Target
Name:
Cell cycle checkpoint protein RAD1
Synonyms:
Cell cycle checkpoint protein RAD1 | DNA repair exonuclease rad1 homolog | RAD1 | RAD1_HUMAN | REC1 | Rad1-like DNA damage checkpoint protein | hRAD1
Type:
PROTEIN
Mol. Mass.:
31814.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109445
Residue:
282
Sequence:
MPLLTQQIQDEDDQYSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES
  
Inhibitor
Name:
BDBM48804
Synonyms:
3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-quinazolinone | 3-(phenylmethyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one | 3-benzyl-2-[(E)-2-(3-pyridyl)vinyl]quinazolin-4-one | 3-benzyl-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one | MLS000709026 | SMR000289793 | cid_5738263
Type:
Small organic molecule
Emp. Form.:
C22H17N3O
Mol. Mass.:
339.3899
SMILES:
O=c1n(Cc2ccccc2)c(\C=C\c2cccnc2)nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: