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Target
Cell cycle checkpoint protein RAD1
Ligand
BDBM39120
Substrate
n/a
Meas. Tech.
ChEMBL_1446559 (CHEMBL3377958)
EC50
5000±n/a nM
Citation
 Huang, F; Mazin, AV Targeting the homologous recombination pathway by small molecule modulators. Bioorg Med Chem Lett 24:3006-13 (2014) [PubMed]  Article 
Target
Name:
Cell cycle checkpoint protein RAD1
Synonyms:
Cell cycle checkpoint protein RAD1 | DNA repair exonuclease rad1 homolog | RAD1 | RAD1_HUMAN | REC1 | Rad1-like DNA damage checkpoint protein | hRAD1
Type:
PROTEIN
Mol. Mass.:
31814.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109445
Residue:
282
Sequence:
MPLLTQQIQDEDDQYSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES
  
Inhibitor
Name:
BDBM39120
Synonyms:
3-chloranyl-1-(3,4-dichlorophenyl)-4-morpholin-4-yl-pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-3-pyrroline-2,5-quinone | MLS-0067124.0001 | cid_1074953
Type:
Small organic molecule
Emp. Form.:
C14H11Cl3N2O3
Mol. Mass.:
361.608
SMILES:
ClC1=C(N2CCOCC2)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1 |c:1|
Structure:
Search PDB for entries with ligand similarity: