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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50045329
Substrate
n/a
Meas. Tech.
ChEMBL_1458115 (CHEMBL3367912)
EC50
4.0±n/a nM
Citation
 Tsuji, T; Suzuki, K; Nakamura, T; Goto, T; Sekiguchi, Y; Ikeda, T; Fukuda, T; Takemoto, T; Mizuno, Y; Kimura, T; Kawase, Y; Nara, F; Kagari, T; Shimozato, T; Yahara, C; Inaba, S; Honda, T; Izumi, T; Tamura, M; Nishi, T Synthesis and SAR studies of benzyl ether derivatives as potent orally active S1P1 agonists. Bioorg Med Chem 22:4246-56 (2014) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50045329
Synonyms:
CHEMBL3311351
Type:
Small organic molecule
Emp. Form.:
C22H29ClNO6P
Mol. Mass.:
469.896
SMILES:
Cc1ccc(CCCC(=O)c2ccc(COC[C@@](C)(N)COP(O)(O)=O)c(Cl)c2)cc1 |r|
Structure:
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