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Target
Potassium voltage-gated channel subfamily E member 1
Ligand
BDBM50045831
Substrate
n/a
Meas. Tech.
ChEMBL_1456351 (CHEMBL3368360)
IC50
>33000±n/a nM
Citation
 Georgsson, J; Bergström, F; Nordqvist, A; Watson, MJ; Blundell, CD; Johansson, MJ; Petersson, AU; Yuan, ZQ; Zhou, Y; Kristensson, L; Kakol-Palm, D; Tyrchan, C; Wellner, E; Bauer, U; Brodin, P; Svensson Henriksson, A GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26. J Med Chem 57:5935-48 (2014) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily E member 1
Synonyms:
Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs
Type:
PROTEIN
Mol. Mass.:
14676.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456351
Residue:
129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP
  
Inhibitor
Name:
BDBM50045831
Synonyms:
CHEMBL3314352
Type:
Small organic molecule
Emp. Form.:
C21H23BrN4O
Mol. Mass.:
427.338
SMILES:
CN(C)Cc1ccc2CN(CCc2c1)C(=O)c1cc2cc(Br)ncc2n1C
Structure:
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