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Target
Poly(ADP-ribose) glycohydrolase
Ligand
BDBM50052831
Substrate
n/a
Meas. Tech.
ChEMBL_1458454 (CHEMBL3370340)
IC50
2900±n/a nM
Citation
 Islam, R; Koizumi, F; Kodera, Y; Inoue, K; Okawara, T; Masutani, M Design and synthesis of phenolic hydrazide hydrazones as potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors. Bioorg Med Chem Lett 24:3802-6 (2014) [PubMed]  Article 
Target
Name:
Poly(ADP-ribose) glycohydrolase
Synonyms:
PARG_RAT | Parg | Poly(ADP-ribose) glycohydrolase
Type:
PROTEIN
Mol. Mass.:
109006.89
Organism:
Rattus norvegicus
Description:
ChEMBL_109458
Residue:
972
Sequence:
MSAGPGCEPCTKRPRWGAAGTSAPTASDSRSFPGRQKRVLDPKDAPVQFRVPPSSSACVSGRAGPHRGSVTSFVFKQKPITTWMDTKGPKTAESESKENNNTRTDPMMSSVQKDNFYPHKVEKLGNVPQLNLDKSPTEKSTPYLNQQQTAGVCKWHSAGERAEQLSASEPSAVTQAPKQLSNANIDQSPPTDGHSDTDHEEDRDNQQFLTPVKLANAKQTVGDGQARSNCKCSASCQCGQDCAGCQREEADVIPESPLSDVGAEDIGTGSKNDNKLTGQESGLGDSPPFEKESEPESPMDVDNSKTSCQDSEADEEASPVFDEQDDQDDRSSQTANKLSSRQAREVDGDLRKRYLTKGSEIRLHFQFEGGSNAGTSDLNAKPSGNSSSLNVDGRSSKQHGKRDSKITDHFVRIPKSEDKRKEQCEVRHQRAERKIPKYVPPNLPPDKKWLGTPIEEMRKMPRCGVRLPLLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCDKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRCCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPPENLSAVATGNWGCGAFGGDARLKALIQLLAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLNVGKVYRLLLRYYREECRDCSSPGPDTKLYPFIYHAAESSAETSDQPGQRTGT
  
Inhibitor
Name:
BDBM50052831
Synonyms:
CHEMBL3318754
Type:
Small organic molecule
Emp. Form.:
C21H13BrCl2N2O4S2
Mol. Mass.:
572.279
SMILES:
OC(=O)CCN1C(=S)S\C(C1=O)=C1/N(Cc2c(Cl)cccc2Cl)c2ccc(Br)cc2C1=O
Structure:
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