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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50060499
Substrate
n/a
Meas. Tech.
ChEMBL_1461693 (CHEMBL3395231)
IC50
4.6±n/a nM
Citation
 Ryu, JH; Kim, S; Han, HY; Son, HJ; Lee, HJ; Shin, YA; Kim, JS; Park, HG Synthesis and biological evaluation of picolinamides as potent inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). Bioorg Med Chem Lett 25:695-700 (2015) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50060499
Synonyms:
CHEMBL3394396
Type:
Small organic molecule
Emp. Form.:
C21H31N3O2
Mol. Mass.:
357.4897
SMILES:
C[C@@]1(O)CC[C@@H](CC1)N(C1CC1)C(=O)c1cccc(n1)N1CCCCC1 |r,wD:5.8,1.1,(1.08,2.13,;,1.54,;-1.08,2.13,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;-0,-3.08,;1.33,-3.85,;2.02,-5.14,;2.79,-3.81,;-1.34,-3.85,;-2.4,-3.23,;-1.34,-5.39,;-2.68,-6.16,;-2.68,-7.7,;-1.34,-8.47,;-.01,-7.7,;-.01,-6.16,;1.33,-8.47,;2.66,-7.7,;3.99,-8.48,;3.99,-10.02,;2.66,-10.78,;1.32,-10.01,)|
Structure:
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