Reaction Details
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Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50377302
Substrate
n/a
Meas. Tech.
ChEMBL_1463127 (CHEMBL3399110)
EC50
30.0±n/a nM
Citation
Zhang, H; Ding, CZ; Lai, Z; Chen, SS; Devasthale, P; Herpin, T; Morton, G; Qu, F; Ryono, D; Smirk, R; Wang, W; Wu, S; Ye, XX; Li, YX; Apedo, A; Farrelly, D; Wang, T; Gu, L; Morgan, N; Flynn, N; Chu, C; Kunselman, L; Lippy, J; Locke, K; O'Malley, K; Harrity, T; Cap, M; Zhang, L; Hosagrahara, V; Kadiyala, P; Xu, C; Doweyko, AM; Zahler, R; Hariharan, N; Cheng, PT Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists. Bioorg Med Chem Lett 25:1196-205 (2015) [PubMed] Article More Info.:
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Inhibitor
Name:
BDBM50377302
Synonyms:
CHEMBL255930
Type:
Small organic molecule
Emp. Form.:
C29H27F3N4O4
Mol. Mass.:
552.5443
SMILES:
Cc1oc(nc1CCOc1ccc(C[C@@H]2CN(C[C@@H]2C(O)=O)c2nccc(n2)C(F)(F)F)cc1)-c1ccccc1
Structure:
