Reaction Details Report a problem with these data
Target
Interleukin-1 receptor antagonist protein
Ligand
BDBM50077028
Substrate
n/a
Meas. Tech.
ChEMBL_1473490 (CHEMBL3419986)
IC50
52±n/a nM
Citation
 Papakyriakou, A; Zervoudi, E; Tsoukalidou, S; Mauvais, FX; Sfyroera, G; Mastellos, DC; van Endert, P; Theodorakis, EA; Vourloumis, D; Stratikos, E 3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties. J Med Chem 58:1524-43 (2015) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor antagonist protein
Synonyms:
IL-1RN | IL1 inhibitor | IL1RA_MOUSE | IRAP | Il-1ra | Il1rn | Interleukin-1 receptor antagonist protein
Type:
PROTEIN
Mol. Mass.:
20273.13
Organism:
Mus musculus
Description:
ChEMBL_109596
Residue:
178
Sequence:
MEICWGPYSHLISLLLILLFHSEAACRPSGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNIKLEEKIDMVPIDLHSVFLGIHGGKLCLSCAKSGDDIKLQLEEVNITDLSKNKEEDKRFTFIRSEKGPTTSFESAACPGWFLCTTLEADRPVSLTNTPEEPLIVTKFYFQEDQ
  
Inhibitor
Name:
BDBM50077028
Synonyms:
CHEMBL3416692
Type:
Small organic molecule
Emp. Form.:
C31H35N5O4
Mol. Mass.:
541.6407
SMILES:
CCCC[C@H](N)C(=O)Nc1cc(ccc1N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: