Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50095069
Substrate
n/a
Meas. Tech.
ChEMBL_1503356 (CHEMBL3590859)
Ki
30±n/a nM
Citation
 Barthel, C; Sorger, D; Deuther-Conrad, W; Scheunemann, M; Schweiger, S; Jäckel, P; Roghani, A; Steinbach, J; Schüürmann, G; Sabri, O; Brust, P; Wenzel, B New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure. Eur J Med Chem 100:50-67 (2015) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50095069
Synonyms:
CHEMBL3589871
Type:
Small organic molecule
Emp. Form.:
C24H28FNO2
Mol. Mass.:
381.483
SMILES:
O[C@@H]1CC[C@H](C[C@H]1N1CCC(=CC1)c1ccccc1)OCc1ccc(F)cc1 |r,c:11|
Structure:
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