Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50100546
Substrate
n/a
Meas. Tech.
ChEMBL_1456739 (CHEMBL3371029)
EC50
26±n/a nM
Citation
 Jeon, MK; Lee, KM; Kim, IH; Jang, YK; Kang, SK; Lee, JM; Jung, KY; Kumar, JA; Rhee, SD; Jung, WH; Song, JS; Bae, MA; Kim, KR; Ahn, JH Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists. Bioorg Med Chem Lett 24:4281-5 (2014) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50100546
Synonyms:
CHEMBL3321837
Type:
Small organic molecule
Emp. Form.:
C24H27FN4O4S2
Mol. Mass.:
518.624
SMILES:
CN(C1CCN(CC1)C(=O)OC1(C)CC1)c1ncnc2c(csc12)-c1ccc(cc1F)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: