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Target
Alpha-enolase
Ligand
BDBM50103566
Substrate
n/a
Meas. Tech.
ChEMBL_1435602 (CHEMBL3386525)
IC50
576±n/a nM
Citation
 Granchi, C; Fancelli, D; Minutolo, F An update on therapeutic opportunities offered by cancer glycolytic metabolism. Bioorg Med Chem Lett 24:4915-25 (2014) [PubMed]  Article 
Target
Name:
Alpha-enolase
Synonyms:
2-phospho-D-glycerate hydro-lyase | 4.2.1.11 | C-myc promoter-binding protein | ENO1 | ENO1L1 | ENOA_HUMAN | Enolase 1 | Enolase 1 (ENO1) | MBP-1 | MBPB1 | MPB-1 | MPB1 | NNE | Non-neural enolase | Phosphopyruvate hydratase | Plasminogen-binding protein
Type:
n/a
Mol. Mass.:
47171.43
Organism:
Homo sapiens (Human)
Description:
P06733
Residue:
434
Sequence:
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
  
Inhibitor
Name:
BDBM50103566
Synonyms:
CHEMBL3335790
Type:
Small organic molecule
Emp. Form.:
C31H43FN8O3
Mol. Mass.:
594.7233
SMILES:
NCCOCCOCCNC(=O)Cc1ccc(Nc2nc(NCC3CCCCC3)nc(NCc3ccc(F)cc3)n2)cc1
Structure:
Search PDB for entries with ligand similarity: