Reaction Details Report a problem with these data
Target
Sialic acid-binding Ig-like lectin 7
Ligand
BDBM50114355
Substrate
n/a
Meas. Tech.
ChEMBL_1511186 (CHEMBL3607813)
IC50
1642000±n/a nM
Citation
 Prescher, H; Gütgemann, S; Frank, M; Kuhfeldt, E; Watzl, C; Brossmer, R Synthesis and biological evaluation of 9-N-oxamyl sialosides as Siglec-7 ligands. Bioorg Med Chem 23:5915-21 (2015) [PubMed]  Article 
Target
Name:
Sialic acid-binding Ig-like lectin 7
Synonyms:
AIRM-1 | AIRM1 | Adhesion inhibitory receptor molecule 1 | CD_antigen=CD328 | CDw328 | D-siglec | QA79 membrane protein | SIGL7_HUMAN | SIGLEC7 | Sialic acid-binding Ig-like lectin 7 | Siglec-7 | p75
Type:
PROTEIN
Mol. Mass.:
51147.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109858
Residue:
467
Sequence:
MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK
  
Inhibitor
Name:
BDBM50114355
Synonyms:
CHEMBL3604070
Type:
Small organic molecule
Emp. Form.:
C14H22N3NaO10
Mol. Mass.:
415.3283
SMILES:
[Na+].[H][C@]1(O[C@@](C[C@H](O)[C@H]1NC(C)=O)(OC)C([O-])=O)[C@H](O)[C@H](O)CNC(=O)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: