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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50115192
Substrate
n/a
Meas. Tech.
ChEMBL_1513596 (CHEMBL3610216)
EC50
530±n/a nM
Citation
 Matsui, Y; Yamaguchi, T; Yamazaki, T; Yoshida, M; Arai, M; Terasaka, N; Honzumi, S; Wakabayashi, K; Hayashi, S; Nakai, D; Hanzawa, H; Tamaki, K Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists. Bioorg Med Chem Lett 25:3914-20 (2015) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50115192
Synonyms:
CHEMBL3609572
Type:
Small organic molecule
Emp. Form.:
C27H25F3O6
Mol. Mass.:
502.479
SMILES:
CC(C)(C)OC(=O)c1c(O)c(ccc1COc1ccc(cc1)-c1cccc(CC(O)=O)c1)C(F)(F)F
Structure:
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