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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50115822
Substrate
n/a
Meas. Tech.
ChEMBL_1512484 (CHEMBL3610255)
IC50
13800±n/a nM
Citation
 Lee, IS; Jung, SH; Lee, YM; Choi, SJ; Sun, H; Kim, JS Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae. J Nat Prod 78:2249-54 (2015) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50115822
Synonyms:
CHEMBL3608476
Type:
Small organic molecule
Emp. Form.:
C13H12O4
Mol. Mass.:
232.232
SMILES:
COc1cc(O)cc(c1)-c1ccc(O)c(O)c1
Structure:
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