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Target
Protein phosphatase 1D
Ligand
BDBM50118477
Substrate
n/a
Meas. Tech.
ChEMBL_1515092 (CHEMBL3614136)
IC50
110±n/a nM
Citation
 Ogasawara, S; Kiyota, Y; Chuman, Y; Kowata, A; Yoshimura, F; Tanino, K; Kamada, R; Sakaguchi, K Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation. Bioorg Med Chem 23:6246-9 (2015) [PubMed]  Article 
Target
Name:
Protein phosphatase 1D
Synonyms:
PP2C-delta | PPM1D | PPM1D_HUMAN | Protein phosphatase 2C isoform delta | Protein phosphatase magnesium-dependent 1 delta | WIP1 | p53-induced protein phosphatase 1
Type:
PROTEIN
Mol. Mass.:
66695.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515094
Residue:
605
Sequence:
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC
  
Inhibitor
Name:
BDBM50118477
Synonyms:
CHEMBL3613748
Type:
Small organic molecule
Emp. Form.:
C24H48O4Si2
Mol. Mass.:
456.8065
SMILES:
[H][C@]12C[C@@H](C[C@@](C)(C(O)=O)[C@]1([H])CCC[C@H]2O[Si](CC)(CC)CC)O[Si](C)(C)C(C)(C)C |r|
Structure:
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