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Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM50120581
Substrate
n/a
Meas. Tech.
ChEMBL_1518045 (CHEMBL3619046)
IC50
14±n/a nM
Citation
 Kusumi, K; Shinozaki, K; Yamaura, Y; Hashimoto, A; Kurata, H; Naganawa, A; Ueda, H; Otsuki, K; Matsushita, T; Sekiguchi, T; Kakuuchi, A; Seko, T Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives. Bioorg Med Chem Lett 25:4387-92 (2015) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
Edg5 | S1PR2_RAT | S1pr2 | Sphingosine 1-phosphate receptor 2 (S1P2)
Type:
Protein
Mol. Mass.:
38749.58
Organism:
Rattus norvegicus (Rat)
Description:
P47752
Residue:
352
Sequence:
MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM50120581
Synonyms:
CHEMBL3618198
Type:
Small organic molecule
Emp. Form.:
C29H25F2N3O4
Mol. Mass.:
517.5233
SMILES:
OC1(CCN(CC1)C(=O)Nc1cc(Oc2ccncc2)cc(Oc2ccc(F)cc2)c1)c1ccc(F)cc1
Structure:
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