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Target
Proteinase-activated receptor 2
Ligand
BDBM50440868
Substrate
n/a
Meas. Tech.
ChEMBL_1549738 (CHEMBL3757294)
IC50
1250±n/a nM
Citation
 Yau, MK; Liu, L; Lim, J; Lohman, RJ; Cotterell, AJ; Suen, JY; Vesey, DA; Reid, RC; Fairlie, DP Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Bioorg Med Chem Lett 26:986-91 (2016) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50440868
Synonyms:
CHEMBL2431617
Type:
Small organic molecule
Emp. Form.:
C32H42N4O4
Mol. Mass.:
546.7003
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:35|
Structure:
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